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  • م.د.حيدر عبد الحافظ كرجي
  • Dr.Hayder Abdulhafedh Kurji
  • عميد : كلية الصيدلة
  • Dean : University Of Pharmacy
  • دكتوراه صيدلة سريرية
  • Ph.D.in clinical pharmacy
  • drhaydar@bauc14.edu.iq
  • Clinicalpharm79@yahoo.com
  • السيرة الذاتية
  • Google Scholar
  • ORCId
  • Research Gate
  • scopus

    • نشاطات التدريسي

    البحوث المنشورة

    المؤلفات

    المقررات المكلف بها

    المحاضرات

    مشاريع التخرج

    المقالات داخل المجلة

    المقررات المكلف بها

    المقررات المكلف بها - 3
    القسم المرحلة الفصل رمز المقرر الوحدات توصيف المقرر
    كلية الصيدلة المرحلة الرابعة فصل اول BH41BIOPHARM. 3 Biopharmaceutics
    كلية الصيدلة المرحلة الخامسة فصل ثاني BH52The.Drug .drug mo.TDM) 3 Therapeutic Drug Monitoring (TDM)
    كلية الصيدلة المرحلة الخامسة فصل ثاني BH52PHAR.Biotech. 1 Pharmaceutical Biotechnology

    المحاضرات الالكترونية

    المحاضرات الالكترونية - 8
    العام المقرر القسم المرحلة المحاضرة
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة Adjustment in Renala nd Hepatic Disease Dose
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة Intravenous Infusion
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة Pharmacokinetics of Oral Absorption
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة Pharmacokinetics Models
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة physicochemical properties of drugs affecting on drug absorption
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة PASSAGE OF DRUGS ACROSS CELL MEMBRANES
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة Physiological factors influencing oral drug absorption
    2024-2025 Biopharmaceutics كلية الصيدلة المرحلة الرابعة Introduction to bio-pharmaceutics

    البحوث

    2020 Journal of Pharmaceutical Sciences and Research
    "The aim of this study is to evaluate the difference in pharmacokinetic parameters between the same brand drugs containing Cephalexin as the active ingredient distributed to both the private sector and the governmental sector in Jordan. Method: Plasma samples of two healthy volunteer groups have been examined at different time intervals after oral administration of Cephalexin 500 mg obtained from both private and governmental health sectors, and the pharmacokinetic parameters such as area under plasma concentration time curve (AUC), maximum plasma concentration (Cmax), and time to reach maximum plasma concentration (Tmax), have been measured after conducting high performance liquid chromatography (HPLC) experiment. Results: Measurements have shown a significant difference in almost all parameters between Cephalexin from the private sector and that from the governmental sector that support the call for more control and regulations on drugs supplied to governmental health sectors. Conclusion: More control on drugs supply for governmental hospitals and health centers and almost all drug companies must provide a proof for bioequivalence for their drugs going to that sector and not rely only on that bioequivalence comparison done for registration and FDA requirements"

    2019 International Journal of Pharmaceutical Quality Assurance
    "The purpose of this study was to compare the efficacy of two recombinant follicle-stimulating hormone (FSH) on pregnancy rates in infertile patients. Material and Methods: between 2015-2017, 387 females intended to have in vitro fertilization (IVF) for infertility treatment (226 patients use Gonal-F and 161 using Puregon. Results: Serum E2 concentration at hCG time was higher with follitropin-a treated patients, and a larger number of retrieved oocyte result in a large number of the transferred embryo, and high pregnancy rate than Follitropin-b treated patients. Conclusions: Gonal-F (Follitropin-a) is associated with a potential stimulatory effect on ovaries. Puregon (Follitropin-b) was associated with a lower clinical pregnancy rate (PR). E2 level 5-7 days after stimulation can be used as an indicator of the success of IV"

    2014 International Journal of Basic & Clinical Pharmacology
    " Insulin resistance impairs nitric oxide (NO) bioavailability; obesity promotes a state of metabolic syndrome and damages the vascular endothelium by altering lipid profile. Phosphodiesterase-5 (PDE-5) inhibitors restore NO signaling may improve metabolic parameters through a number of mechanisms. We hypothesized that daily administration of the PDE-5 inhibitor; sildenafil will improve fasting plasma glucose (FPG), triglyceride (TG) levels and body weight, in obese diabetic patients. Methods: Totally, 25 obese diabetic male patients with metabolic syndrome treated with sildenafil 25 mg daily for 3 months. Body weight, FPG levels, and lipid profile were determined monthly. Results: Treatment with sildenafil caused a reduction in fasting glucose levels, fasting TGs, cholesterol, low-density lipoprotein (LDL), very-LDL and increased high-density lipoprotein; body weight was significantly reduced. Conclusion: We have provided the first evidence that sildenafil therapy improve glycemic control, lipid profile and body mass index in diabetic patients with metabolic syndrome"

    2006 Euro-Mediterranean Council for Burns and Fire Disasters (MBC)
    The aim of this study was to prevent eschar formation in thermally injured patients during the use of povidoneiodine ointment by modifying therapeutic protocols depending on normal events in healing process. Sixty thermally injured patients of different age groups, sex, and occupation with different burn sizes were involved in the study, allocated to two groups. Group A was made up of 17 patients treated with topical povidone-iodine ointment in addition to other prescribed drugs according to the burn unit regimen, while group B was comprised of 43 patients treated with topical povidone-iodine ointment for the first four days post-injury followed by topical silver sulphadiazine cream until discharge and with other prescribed drugs according to the burn unit regimen. In both groups the following were studied, using standard methods: oxidative stress parameters; thyroid, liver, and renal function test; microbiology

    2013 International Journal of Science and Research (IJSR)
    Obesity promotes a state of metabolic syndrome and damages the vascular endothelium by altering lipid profile. Phosphodiesterase-5 (PDE-5) inhibitors restore NO signaling may improve metabolic parameters through a number of mechanisms. We hypothesized that daily administration of the PDE-5 inhibitor; Tadalafil will improve fasting plasma glucose (FPG), triglyceride (TG) levels and body weight, in obese diabetic patients. Methods: Totally, 20 obese diabetic male patients with metabolic syndrome treated with Tadalafil 10 mg daily for 3 months. Body weight, FPG levels, and lipid profile were determined monthly. Results: Treatment with Tadalafil caused a reduction in fasting glucose levels, fasting TGs, cholesterol, low-density lipoprotein (LDL), very-LDL and increased high-density lipoprotein; body weight was significantly reduced. Conclusion: Tadalafil therapy improves glycemic control, lipid profile and body mass index in diabetic patients with metabolic syndrome

    2022 HIV Nursing
    "VASP, an actin-regulatory protein family member, controls platelet adhesion. Ticagrelor isthe first member of a brand-new agent of chemicals, thecyclopentyltriazolopyrimidines, is Ticagrelor. ADP's prothrombotic effects can be prevented by Ticagrelor's ability to block the platelet P2Y12 receptor, just as the thienopyridines. Dissimilar the thienopyridines, which are irreversible inhibitors, reversibly binding to the P2Y12 receptor, Ticagrelor almost entirely blocks ADP-stimulated platelet aggregation, as demonstrated in vitro. Because it does not require metabolic activation, Ticagrelor is an alternative to the thienopyridines. All patients receiving Ticagrelor achieve adequate antiplateleteffects. Objective: Inthis study, we examined the roleof platelet reactivity index (PRI) in antiplatelet treatment and its association with vasodilator stimulated phosphoprotein (VASP) for Iraqi patient undergoing percutaneouscoronary intervention (PCI). Methods: In this study, patients who were eligible for PCI were included. At least two weeks after a 90-mg dose of ticagrelor was administered following PCI, blood samples were collected from patients. Vasodilator-stimulated phosphoprotein phosphorylation assay (VASP-P) was used to detect the inhibition percentage of platelet adhesion. Consistently high or low levels of platelet activationon therapy can be identified by the evaluation ofplatelet reactive index (PRI) using the VASPELISA assay. Results: The body mass index (BMI) was significant higher in patients with coronary heartdisease contrasted to thecontrol group (P< 0.001). There was a significant difference inthe platelets count in patientswith coronary"

    2022 Kerbala journal of pharmacy and pharmaceutical science
    The earth has openhandedly offered a huge number of different herbs like ribwort, thyme, rosemary, basil, sage, cardamom, chamomile, and mint, which are rich in different types of polyphenols with potent biochemical and antioxidant characteristics. This paper concentrates on many natural phenolic acids and their common natural herbal origins. A summary of recent reports of antioxidant effects of phenolics in emulsions (o/w) is delivered as a lipid-based in the vitro-model system. Additionally, exploring the activities of phenolic acids could serve to elucidate their possible health effects toward oxidative conditions. Lastly, this review depends on the newest literature evidence that concerns specific biochemical characteristics of the studied phenolic acids.

    2021 Indian Journal of Forensic Medicine & Toxicology
    "Background: Antibiotics are one of the most commonly prescribed drugs today. Rational use of antibiotics is extremely important as injudicious use can adversely affect the patient, cause emergence of antibiotic resistance and increase the cost of health care; Antibiotics resistance is out of the scope of this study. Methods: This study was carried out on (600) patients with age range (34.4±16.9 years), of both sexes; to whom ceftriaxone was prescribed for different medical and surgical causes that dispensed in private community pharmacy in Baquba, Diyala; over the period of four months. The selected patients were allocated into 2 groups: Group A (300) patients to whom ceftriaxone prescribed without clinical pharmacist intervention considering guidelines for antibiotic prescription, compared with group B (300) patients to whom Ceftriaxone prescribed with clinical pharmacist intervention depending on standard guideline. To each group the following information were collected: age, sex, diagnosis, number of days were ceftriaxone prescribed, dose given, laboratory tests done to patients during hospitalization and drug interaction if present in addition to other parameters designed according to this study. Results: Results obtained in this study showed that prescription of Ceftriaxone depending on clinical pharmacist intervention regarding standard guideline of antibiotic improve the Ceftriaxone true dose%, reduce occurrence of drug interaction (%), decrease significantly (P< 0.05) Ceftriaxone misuse ratio and significantly (P< 0.05) reduce amount and cost of Ceftriaxone prescribed per month. Conclusion: Strictly following clinical pharmacist intervention"

    2013 World Journal of Pharmaceutical Research
    "Background: Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset. However, little is known about the effect of obesity on treatment efficacy. Women who are obese continue to have higher levels of estrogen than women of normal weight even after treatment with hormone- suppressing drugs ,raising the possibility that they might benefit from modification or changes to their treatment. Objective: The aim of this work is to study the effect of body mass index on biochemical, hematological, trace elements, and estrogen level of obese and non-obese Iraqi postmenopausal women with breast cancer in comparison with postmenopausal obese and nonobese women who had no breast cancer. Material and Methods: A hospital based case control study was carried out at Baquba Teaching Hospital, Diyala, Iraq. The analysed variables were age, metabolic profile including total cholesterol, triglycerides, HDL-C, blood sugar, total protein , albumine, urea, uric acid, Ca, Na, Cl, phosphate, heamatological parametes, zinc, copper and selenium. Descriptive statistics and testing of hypothesis were used for the analysis usingMean± SD testP≤0.05. Results: lipid profile showed significant variability among studied group in this study, also fasting blood sugar showed significant differences between groups, serum estradiol highly increased in postmenapausal obese with breast cancer, significant hematological variations had been seen among studied groupps; serum cupper increased in obese breast cancer while zinc ,selenium decreased, serum k highly increased in postmenapausal obese breast cancer. Conclusions: From this study, we can interested with several mechanisms involved in pathogenesis of breast cancer, from which we can evaluate the treatment of breast cancer including hormonal therapy especially in obese postmenopausal women which may required modification in treatment protocols to improve outcomes ."

    2009 Diala, Jour, Volume, 37, 2009
    "Antibiotics are one of the most commonly prescribed drugs today. Rational use of antibiotics is extremely important as injudicious use can adversely affect the patient, cause emergence of antibiotic resistance and increase the cost of health care; Antibiotics resistance is out of the scope of this study. Methods: This study was carried out on (686) patients with age range (39.4±20.9 years), of both sexes; to whom cefotaxime was prescribed for different medical and surgical causes in Baquba Teaching Hospital-Diyala; over the period of three months. The selected patients were allocated into 2 groups: Group A (650) patients to whom cefotaxime prescribed without considering any guidelines for antibiotic prescription, compared with group B (36) patients to whom cefotaxime prescribed depending on standard guideline. To each group the following information were collected: age, sex, diagnosis, number of days were cefotaxime used, dose given, laboratory tests done to patients during hospitalization and drug interaction if present in addition to other parameters designed according to this study. Results: Results obtained in this study showed that prescription of cefotaxime depending on standard guideline of antibiotic improve the cefotaxime true dose%, reduce occurrence of drug interaction (%), decrease significantly (P< 0.05) cefotaxime misuse ratio and significantly (P< 0.05) reduce amount and cost of cefotaxime prescribed per month. Conclusion: Strictly following standard guidelines for antibiotic prescription; and involvement of clinical pharmacist in the team work improve therapeutic process outcome, prevent many "

    2019 World Journal of Pharmaceutical and Life Sciences
    "Introduction: The kidney is the main site for the synthesis of Erythropoietin, which represents the circulating hormone responsible for stimulatory effect on bone marrow for the erythropoiesis. In case of chronic kidney disease (CKD), Erythropoietin deficiency is the main cause of anemia. Erythropoietin synthesis by DNA technology results in revolution in the management strategies of anemia in CKD. This study aimed to evaluate the effect of different doses (different serum concentration) of erythropoietin on anemia treatment outcome in different stages of renal disease. Material and methods: this prospective study was conducted on 245 patients categorized into three groups according to their stage of renal disease. Serum concentration of Erythropoietin, HGB, Transferrin, Ferritine, RBC, and hsCRP were measured using spectrophotometric and immunochemical procedures. Results: There was a significant reduction in hematocrit, HGB in patients with advanced stage kidney disease in comparison to early stage p=0.00567, p=0.00533. Transferrin was significantly less in stage V in comparison to early stage of renal disease p=0.00635. Ferritin was significantly higher in stage V comparing to that of early stage of renal disease. Serum concentration of erythropoietin was directly correlated with hematocrit and Hb in early stage of renal disease EP0 R² = 0.597 Hct, R² = 0.674 HB, whereas, in patients with stage 5 renal disease, erythropoietin is poorly correlated with hematocrit and Hb, EP0 R² = 0.05353 Hct R² =0.064 HGB. Conclusion: Advanced renal failure is associated with lack of erythropoietin and consequently result in severe anemia. The stimulatory effect on bone marrow by erythropoietin is reduced with progression of renal disease."

    2022 Medical and Pharmaceutical Journal
    "Abstract In addition to energy storage, the adipose tissue plays multiple important roles, particularly the secretion of biomolecules such as leptin that participate in the neuroendocrine regulation of appetite. Therefore, this review sought to understand the influence of leptin on the genesis of obesity. A systemic review of the literature was conducted using articles published in English between 2016 and 2022. Ten experi- mental studies that introduced new approaches for treating leptin-resistant individuals were selected. The results showed that a structured food plan with a negative energy balance combined with a regular physi- cal activity routine remains the best way to combat obesity and leptin resistance problems. It is possible to conclude that leptin resistance contributes to maintaining obesity. However, to date, there remains a lack of evidence that demonstrates a direct relationship between the poor function of this peptide and the genesis of obesity."




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